Having suffered defeat in their respective openers, both sides head into the clash now in the last chance saloon to preserve their World Cup campaign.
Cameroon and Serbia will go head to head for the first time in a competitive fixture with their only previous encounter coming back in an international friendly 12 years ago.
If that game is anything to go by, then we can expect a goalfest at the Al Janoub Stadium tomorrow following a 4-3 victory for Serbia in their last meeting against Monday's opponents.
A first-half brace from Pierre Webo put Cameroon in the driving seat after which goals from Dejan Stankovic, Nenad Milijas and Marko Pantelic turned the contest on its head.
Milos Krasic also got in the act to put Dragan Stojkovic's men 4-2 up before Eric Maxim Choupo-Moting pulled one back to set up a thrilling finale.
Since then, Rigobert Song's men have lost five straight matches against European teams in major tournaments, the most recent of which was against Switzerland last time out.
CAMEROON VS. SERBIA HEAD-TO-HEAD RECORD
Cameroon wins: 0
Serbia wins: 1
Draws: 0
Cameroon goals: 3
Serbia goals: 4
MATCH HISTORY
June 05, 2010: Cameroon 3-4 Serbia (Friendly)
Read more on Cameroon vs Serbia
Click here to read our full preview for Cameroon vs Serbia
How Cameroon could line up against Serbia
How Serbia could line up against Cameroon
Azerbaijan 
Estonia 
Georgia 
Ukraine 
Andorra 
Moldova 
Montenegro 
Iceland 
Turkey 
Wales 
Albania 
Czech Republic 
Sweden 
Slovakia 
Germany 
Bosnia & Herzegovina 
Netherlands 
Hungary 
Latvia 
Armenia 
North Macedonia 
Faroe Islands 
Bordeaux 
England 
Rep. Of Ireland 
Finland 
Greece 
Austria 
Slovenia 
Norway 
Kazakhstan 
Israel 
Belgium 
Italy 
France 
Croatia 
Portugal 
Liechtenstein 
San Marino 
Poland 
Scotland 
Kosovo 
Lithuania 
Romania 
Cyprus 
Bulgaria 
Belarus 
Luxembourg 
Northern Ireland 
Serbia 
Denmark 
Spain 
Switzerland 
Russia 
Syria