The Hammers enjoyed a superb season in Europe last season, reaching the semi-finals of the Europa League before losing to eventual champions Eintracht Frankfurt.
They finished seventh in the Premier League and will now be looking to qualify for Europe's third competition this term.
First, they face a two-legged play-off clash against Viborg.
Jacob Friis' Greens also claimed seventh in the Danish Superliga last season and West Ham will be eager to avoid a slip up against the minnows.
West Ham v Viborg FF: Date and how to follow
This Europa Conference League play-off tie will take place on Thursday, August 18.
The game at the London Stadium is scheduled to kick off at 7:45pm.
This match will be broadcast on BT Sport 1 with coverage starting at 7:15pm.
BT Sport customers can live stream this via the app using their mobile, tablet or computer devices.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
West Ham v Viborg FF: Team news
West Ham will likely rotate their squad for this match ahead of the visit of Brighton in the Premier League on Sunday.
New signings GianlucaScamacca, FlynnDownes and Maxwel
Advertisement
Cornet could all make their first starts for the Hammers.
NayefAguerd remains out with an ankle injury while AngeloOgbonna and Craig
Advertisement
Dawson are not fully fit yet.
AlphonseAreola will likely start in goal.
West Ham v Viborg FF: What has been said?
Former West Ham defender Winston Reid joined the Hammers from Viborg's Danish rivals Midtjylland in 2010.
On this tie, he said: "Viborg is about 45 minutes' drive from Herning, the city where Midtjylland play, so they were our rivals, as you say.
"Viborg were an up-and-down club for a few seasons but they came up a couple of years ago and are doing well now.
"When I was growing up, they were quite a bit club and won the Danish Cup and played in Europe.
"This is a big game for them and their players will see it as a chance to play against a Premier League team and potentially catch the eye, a bit like when players from smaller clubs play against Premier League teams in the FA Cup."
Toulouse 
Montpellier 
Bordeaux 
Ajaccio 
Luton 
Everton 
Arsenal 
Bournemouth 
Leicester 
Blackburn 
Borussia Dortmund 
FC Augsburg 
VFB Stuttgart 
Bayern Munich 
VFL Wolfsburg 
SV Darmstadt 98 
Werder Bremen 
Borussia Monchengladbach 
Celtic 
Heart Of Midlothian 
Real Madrid 
Cadiz 
Monaco 
Clermont Foot 63 
Monza 
Lazio 
Manchester City 
Wolverhampton 
Girona 
Barcelona 
Sassuolo 
Inter 
Mallorca 
Atletico Madrid 
Chaves 
FC Porto 
PSV 
Sparta Rotterdam 
Rangers 
Kilmarnock 
Volendam 
Ajax 
Dynamo Kyiv 
Kolos Kovalivka 
Chelsea 
West Ham 
Sampdoria 
Reggiana 
Espanyol 
Sporting Gijon 
AZ Alkmaar 
Twente 
Shakhtar Donetsk 
Chornomorets Odesa 
Liverpool 
Tottenham 
Eintracht Frankfurt 
Bayer Leverkusen 
AC Milan 
Genoa