The Hammers narrowly lost to the La Liga side last week in Seville, with a goal from Munir El Haddadi separating the two.
David Moyes' side carved out a number of opportunities and Nikola Vlasic should have scored in the first half, while Manuel Lanzini was denied by a Jesus Navas block late on.
Sevilla also had chances to extend the lead and Munir could have ended the game with a hat-trick.
However, the match is tightly poised and the Irons can cause this Sevilla side problems at the London Stadium.
The La Liga side have only conceded 19 goals in the league, but they did look vulnerable to West Ham's pace and power.
The Hammers have lost six games at the London Stadium this season but are unbeaten in six of their last seven.
West Ham v Sevilla: Date and start time
This Europa League game will take place on Thursday, March 17.
The London Stadium game is scheduled to kick off at 8pm in the UK.
The meeting last week was the first time these two teams have ever played each other.
West Ham v Sevilla: TV channel and live stream
The match will be broadcast on BT Sport 2 with live coverage starting at 7:15pm.
BT Sport customers can live stream this via the app using their mobile, tablet or computer devices.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
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West Ham v Sevilla: Team news
The Hammers have a few major injury concerns to key players, with Jarrod Bowen ruled out until after the international break by Moyes.
The former Manchester United boss is also set to make a late call on Michail Antonio and Aaron Cresswell.
However, he confirmed that he wouldn't risk either if he doesn't believe they are fully fit.
If Antonio misses out, Moyes could start Andriy Yarmolenko after his goal on Sunday against Aston Villa.
It was an emotional day for Yarmolenko but Moyes has praised his mental strength for coming through it.
The La Liga side also have problems and will definitely be without Erik Lamela and Suso.
There are also concerns over Diego Carlos, Fernando, Papu Gomez and Gonzalez Montiel.
However, Julen Lopetegui will have Thomas Delaney back after his suspension and potentially Ivan Rakitic.
The Croatian pulled up before the game last Thursday but he could be involved tomorrow.
West Ham v Sevilla: What has been said?
David Moyes said: "If you're second in La Liga, you have to be some side. There are great sides in it and top, top players. Sevilla are a side experienced in winning this trophy.
"We want to challenge the best and I think Sevilla are among the best at the moment."