Ronaldo inspired United to a 4-1 win over Newcastle last weekend as he announced his return to the English top-flight in style.
The Red Devils are yet to beaten in the league this season but will want to hit back from their surprise Champions League loss at Young Boys in midweek.
West Ham, meanwhile, have enjoyed a fine start to the campaign too and are also undefeated.
The Hammers drew with Southampton last time out and David Moyes will be eager to get one over his old employers this Sunday.
West Ham v Man United: Date and time
The Premier League clash will take place on Sunday, September 19.
The match at St James' Park will kick off at 2pm.
United beat West Ham three times last season including a 3-1 victory in east London.
West Ham v Man United: TV channel and live stream
The game is being broadcast on Sky Sports Premier League from 1pm and on Sky Sports Main Event from 2pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
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West Ham v Man United: Team news
West Ham will be without star man Michail Antonio following his red card last time out.
The Hammers have no further issues to deal with.
Nikola Vlasic and Alex Kral will be pushing for their first league starts since joining on deadline day.
For United, Edinson Cavani, Marcus Rashford and Alex Telles remain out while Scott McTominay may not be fit enough to start yet.
Fred is available again while Anthony Martial could come into the starting line-up.
West Ham v Man United: Match facts
West Ham have won two of their last six Premier League games against Man Utd (D1 L3), though they are winless in three against the Red Devils. The Hammers had won just one of their previous 19 against them in the competition (D5 L13).
Manchester United have won their last two Premier League meetings with West Ham, last winning three in a row against the Hammers in September 2014.
West Ham are unbeaten in their last seven Premier League games (W4 D3), their longest run in the competition since a streak of 10 games between February and April 2016.
Manchester United are unbeaten in 28 Premier League away games, the longest ever run without defeat on the road in English league history. The Red Devils have conceded just 19 goals in this run, keeping 13 clean sheets in the process.
After losing consecutive games against Tottenham and Arsenal last season, Manchester United are unbeaten in their last 16 Premier League games on Sundays (W11 D5). In Premier League history, the Red Devils have the highest win rate in Sunday games (min. 10 games) - 55% (163/297).
Since leaving Manchester United in 2014, West Ham boss David Moyes has failed to win any of his seven games against the Red Devils in all competitions (D2 L5).
Since his debut for West Ham in September 2015, the Hammers have won 41% of their Premier League games in which Michail Antonio has started (56/137), compared to just 28% when he doesn't start (25/90).
Man Utd's Cristiano Ronaldo was involved in six goals in his last four Premier League appearances against West Ham in his first spell in the competition (5 goals, 1 assist). However, only against Chelsea (4) has the Portuguese ended on the losing side in the Premier League more than he has against the Hammers (3).
Manchester United's Paul Pogba has seven assists in the Premier League this season, more than in his previous two campaigns combined (6) and a record four games into a campaign in the competition. Indeed, only two players have had as many as seven assists in their team's first five games - Thierry Henry in 2004-05 and Harry Kane last season.
Man Utd's Jesse Lingard scored nine goals in 16 Premier League appearances on loan at West Ham last season. The Hammers have had the most different players score both for and against them in the competition (46 - excl. OGs), with Lingard potentially adding to this list.