After Dion Charles gave the League One side a shock lead, Luiz levelled in spectacular style as his corner from the left flew over Joel Dixon and into the net.
A Danny Ings penalty as well as strikes from Lucas Digne and Leon Bailey made it a comfortable evening for the Villans in the end.
Gerrard's former manager at Liverpool, Brendan Rodgers, was given a huge fright with his Leicester side needing penalties to get past League Two Stockport County.
The two sides played out a goalless draw at Edgeley Park, however, the Foxes ran out 3-1 winners in the shootout with debutant Daniel Iversen saving two penalties.
There was also some respite for Frank Lampard as his Everton side got the better of Fleetwood Town, Demarai Gray's first-half goal sealing the 1-0 win.
Goal of the night may well go to Adama Traore, who fired in a stunning left-footed volley during Wolves' 2-1 win at home to Preston.
The biggest shock of the night came at Crawley Town, who beat Fulham 2-0. talkSPORT's Alex Crook described the much-changed Cottagers' performance as 'rubbish.'
Elsewhere, Nottingham Forest made light work of Grimsby Town with a goal from Adam Yates and two from Sam Surridge sealing a 3-0 win for the Premier League new boys.
Bournemouth beat Championship side Norwich 5-3 on penalties after playing out an entertaining 2-2 draw, while Crystal Palace won 2-0 at Oxford United.