Kane only joined in group training on Friday following his late return from holiday as he tries to force through a move to Sunday's opponents.
New signing Cristian Romero will be assessed after his injury while Japhet Tanganga is fit after coming off in the last pre-season friendly with an abductor issue.
City are without midfielders Kevin De Bruyne (ankle) and Phil Foden (foot) as the pair continue to recover from injuries suffered at Euro 2020.
Record signing Jack Grealish could make his Premier League debut after featuring as a substitute in the Community Shield last week.
Kyle Walker, John Stones, Raheem Sterling, Gabriel Jesus and Ederson are all back in contention after returning to training this week.
Tottenham provisional squad: Lloris, Gollini, Tanganga, Doherty, Aurier, Romero, Sanchez, Dier, Rodon, Davies, Reguilon, Skipp, Hojbjerg, Sissoko, Lo Celso, Alli, Moura, Bergwijn, Gil, Son, Kane.
Manchester City provisional squad: Ederson, Steffen, Carson, Walker, Cancelo, Stones, Ake, Dias, Laporte, Mendy, Zinchenko, Fernandinho, Gunodgan, Rodri, Grealish, Sterling, Torres, Mahrez, Silva, Palmer, Doyle, Jesus.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow