The two teams head into this contest off the back of FA Cup wins last weekend, with the Saints beating Crystal Palace and the Citizens cruising to victory over Chelsea, and here, Sports Mole rounds up all of the latest team news for the two clubs.
SOUTHAMPTON vs. MANCHESTER CITY
SOUTHAMPTON
Out: Armel Bella-Kotchap (knee), Stuart Armstrong (unspecified)
Doubtful: Valentino Livramento (knee), Juan Larios (muscle), Theo Walcott (calf), Alex McCarthy (ankle)
Sports Mole's predicted XI: Bazunu; Lyanco, Caleta-Car, Salisu; Walker-Peters, Ward-Prowse, Lavia, Perraud; Edozie, A. Armstrong; Adams
MANCHESTER CITY
Out: Ruben Dias (hamstring)
Doubtful: Jack Grealish (illness)
Sports Mole's predicted XI: Ortega; Lewis, Stones, Akanji, Ake; De Bruyne, Phillips, Gundogan; Mahrez, Alvarez, Grealish
For data analysis of the most likely results, scorelines and more for this match please click here.