With Craig Dawson serving a ban for five yellow cards, head coach Gary O'Neil had to contemplate how to tinker with a side that defeated Tottenham Hotspur before the international break.
While Matt Doherty had been an option, O'Neil has instead selected summer arrival Bueno, who has only featured in a 3-2 EFL Cup defeat at Ipswich Town, to feature in the back three.
Pablo Sarabia had put himself in contention for a start after providing a goal and an assist versus Spurs, but the playmaker remains among the replacements.
That is a consequence of O'Neil making no further alterations, the likes of Tommy Doyle and Sasa Kalajdzic also being kept in reserve.
Meanwhile, Fulham boss Marco Silva has made two changes to the Fulham XI that started the 3-1 defeat at Aston Villa on November 12.
Joao Palhinha is absent due to five yellow cards, while Bobby Decordova-Reid also misses out and features on the substitutes' bench.
Harrison Reed and Tom Cairney are the players to come into the Cottagers' starting lineup, while former Wolves forward Raul Jimenez leads the line for the West Londoners.
Fulham: Leno; Castagne, Ream, Bassey, Robinson; Reed, Cairney; Iwobi, Pereira, Willian; Jimenez
Subs: Rodak, Tete, Adarabioyo, Ballo-Toure, Lukic, Wilson, Decordova-Reid, Harris, Vinicius
Wolverhampton Wanderers: Sa; Semedo, S.Bueno, Kilman, Toti, Ait-Nouri; Gomes, Lemina; Bellegarde, Cunha, Hwang
Subs: Bentley, Doherty, Traore, Silva, H.Bueno, Kalajdzic, Jonny, Doyle, Sarabia