Forest advanced to this stage by beating Grimsby Town 3-0 at the end of August, but this match will mark Tottenham's first fixture in this season's tournament, and here Sports Mole rounds up the team news.
NOTTINGHAM FOREST vs. TOTTENHAM HOTSPUR
NOTTINGHAM FOREST
Out: Omar Richards (calf), Harry Toffolo (thigh), Giulian Biancone (knee), Jack Colback (back), Moussa Niakhate (thigh)
Doubtful: None
Sports Mole's predicted XI: Hennessey; Aurier, Worrall, Boly, Lodi; O'Brien, Yates, Mangala; Lingard, Awoniyi, Surridge
TOTTENHAM HOTSPUR
Out: Son Heung-min (eye)
Doubtful: Cristian Romero (thigh), Richarlison (calf)
Sports Mole's predicted XI: Forster; Doherty, Sanchez, Tanganga, Lenglet, Sessegnon; Skipp, Bentancur, Bissouma; Lucas, Gil
For data analysis of the most likely results, scorelines and more for this match please click here.