Milan have twice beaten their southern rivals this month using the same lineup and should stick with that XI at Stadio Maradona, but Napoli will be forced into some changes.
The hosts have Victor Osimhen returning to the fold, though, so will not be without hope of overturning their one-goal deficit. Here, Sports Mole rounds up the latest team news for either side.
NAPOLI vs. AC MILAN
NAPOLI
Out: Kim Min-jae (suspension), Andre-Frank Zambo Anguissa (suspension), Giovanni Simeone (thigh)
Doubtful: None
Sports Mole's predicted XI: Meret; Di Lorenzo, Rrahmani, Jesus, Rui; Ndombele, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
AC MILAN
Out: Zlatan Ibrahimovic (thigh)
Doubtful: None
Sports Mole's predicted XI: Maignan; Calabria, Kjaer, Tomori, Hernandez; Krunic, Tonali; Diaz, Bennacer, Leao; Giroud
For data analysis of the most likely results, scorelines and more for this match please click here.