The Red Devils enter the contest on the back of a 3-2 Champions League loss to Galatasaray, while the Bees drew 1-1 with Nottingham Forest last weekend, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. BRENTFORD
MANCHESTER UNITED
Out: Sergio Reguilon (hamstring), Amad Diallo (knee), Luke Shaw (muscle), Aaron Wan-Bissaka (thigh), Jadon Sancho (disciplinary), Lisandro Martinez (foot), Tyrell Malacia (knee)
Doubtful: Kobbie Mainoo (ankle)
Sports Mole's predicted XI: Onana; Dalot, Varane, Evans, Amrabat; Casemiro, Mount; Antony, Fernandes, Rashford; Hojlund
BRENTFORD
Out: Rico Henry (knee), Josh Dasilva (hamstring), Kevin Schade (groin), Shandon Baptiste (shoulder), Ben Mee (calf), Mikkel Damsgaard (knee), Ivan Toney (suspended)
Doubtful: None
Sports Mole's predicted XI: Flekken; Roerslev, Collins, Pinnock, Hickey; Jensen, Norgaard, Janelt; Mbeumo, Maupay, Wissa
For data analysis of the most likely results, scorelines and more for this match please click here.