Both sides have been afflicted by injuries of late, with the visitors' recently revamped defence being put under particular strain. Nonetheless, two strong XIs are still expected to line up in Lombardy, and here Sports Mole rounds up the latest team news ahead of their midweek encounter.
INTER MILAN vs. BARCELONA
INTER MILAN
Out: Romelu Lukaku (thigh), Marcelo Brozovic (thigh), Alex Cordaz (knee)
Doubtful: None
Sports Mole's predicted XI: Handanovic; Skriniar, Acerbi, Bastoni; Dumfries, Barella, Asllani, Calhanoglu, Dimarco; Martinez, Dzeko
BARCELONA
Out: Ronald Araujo (thigh), Hector Bellerin (calf), Memphis Depay (thigh), Frenkie De Jong (thigh), Jules Kounde (hamstring)
Doubtful: Gavi (muscular)
Sports Mole's predicted XI: Ter Stegen; Roberto, Christensen, Garcia, Alba; Kessie, Busquets, Pedri; Dembele, Lewandowski, Raphinha
For data analysis of the most likely results, scorelines and more for this match please click here.