Dayot Upamecano and Adrien Rabiot have both been suffering with illness in recent days and miss out on a starting spot in this last-four showdown.
Instead, Ibrahima Konate and Youssouf Fofana come into the team at centre-back and in central midfield respectively in what are the only two alterations from the 2-1 triumph over England.
While France have been dealt with two blows ahead of this fixture, Morocco have received a triple boost with Nayef Aguerd, Romain Saiss and Noussair Mazraoui all being passed fit to play.
Aguerd missed the quarter-final win over Portugal with a groin injury, Saiss was forced off with a hamstring problem in that fixture and Mazraoui was also absent at left-back.
Despite being able to select his strongest back four, it appears that Atlas Lions boss Walid Regragui has opted for a back five, including Jawal El Yamiq alongside Aguerd and Saiss.
Selim Amallah is the player to miss out in midfield, while Walid Cheddira is unable to take his spot on the substitutes' bench due to suspension.
The winner of this fixture will progress through to the final to face Argentina, who eased to a 3-0 victory over Croatia on Tuesday night.
France: Lloris; Kounde, Varane, Konate, T.Hernandez; Tchouameni, Y.Fofana; O.Dembele, Griezmann, Mbappe; Giroud
Morocco: Bounou; Hakimi, Aguerd, El Yamiq, Saiss, Mazraoui; Ounahi, Amrabat; Ziyech, En-Nesyri, Boufal