Mauricio Pochettino's men trounced Aston Villa 3-1 in their FA Cup fourth-round replay in midweek, while the Eagles were battered 4-1 by Brighton & Hove Albion last weekend, and here Sports Mole rounds up the team news for both sides.
CRYSTAL PALACE vs. CHELSEA
CRYSTAL PALACE
Out: Michael Olise (hamstring), Marc Guehi (knee), Cheick Doucoure (Achilles), Rob Holding (ankle), Eberechi Eze (thigh), Jesurun Rak-Sakyi (thigh)
Doubtful: Joel Ward (thigh)
Sports Mole's predicted XI: Henderson; Munoz, Richards, Andersen, Mitchell; Hughes, Wharton, Lerma; Ayew, Mateta, Schlupp
CHELSEA
Out: Benoit Badiashile (groin), Robert Sanchez (knee), Marc Cucurella (ankle), Wesley Fofana (knee), Reece James (thigh), Lesley Ugochukwu (hamstring), Romeo Lavia (thigh)
Doubtful: Levi Colwill (unspecified), Trevoh Chalobah (fitness)
Sports Mole's predicted XI: Petrovic; Gusto, Disasi, Silva, Chilwell; Fernandez, Caicedo; Madueke, Gallagher, Palmer; Jackson
For data analysis of the most likely results, scorelines and more for this match please click here.