Last time out, the Blues produced one of their best performances of the season to run out 3-1 victors over Aston Villa in their FA Cup fourth-round replay.
However, a groin injury sustained by Benoit Badiashile forces Mauricio Pochettino to tinker with his defence, the Argentine choosing to bring Thiago Silva back into the team.
Pochettino has stuck with the front three of Noni Madueke, Cole Palmer and Nicolas Jackson, the latter again expected to be deployed on the left flank.
On the substitutes' bench, there is a welcome return for Levi Colwill, after four games out with a tendon injury, and Trevoh Chalobah for the first time this season after a thigh injury.
Meanwhile, Roy Hodgson has made just the two alterations to the side that suffered a 4-1 defeat at Brighton & Hove Albion nine days ago.
Defender Marc Guehi misses out through injury, resulting in Chris Richards moving from defensive-midfield to centre-back.
That switch sees Adam Wharton come into the team for his first start since a big-money move from Blackburn Rovers, while Matheus Franca has been given the nod ahead of Jeffrey Schlupp.
Crystal Palace: Henderson; Munoz, Richards, Andersen, Mitchell; Lerma, Wharton, Hughes; Franca, Mateta, Ayew
Subs: Johnstone, Ward, Tomkins, Clyne, Riedewald, Ozoh, Schlupp, Ahamada, Edouard
Chelsea: Petrovic; Gusto, Disasi, Silva, Chilwell; Caicedo, Fernandez, Gallagher; Madueke, Palmer, Jackson
Subs: Bergstrom, Chalobah, Colwill, Gilchrist, Casadei, Chukwuemeka, Mudryk, Sterling, Nkunku
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