The Bees overcame Newport County on penalties to make it this far, while the Gunners bypassed the first two rounds owing to their participation in European football, and here Sports Mole rounds up the team news for both clubs.
BRENTFORD vs. ARSENAL
BRENTFORD
Out: Ivan Toney (suspended), Josh Dasilva (hamstring), Shandon Baptiste (shoulder), Rico Henry (knee), Neal Maupay (cup-tied), Mikkel Damsgaard (groin), Ben Mee (knock), Kevin Schade (groin)
Doubtful: None
Sports Mole's predicted XI: Strakosha; Roerslev, Zanka, Ajer, Hickey; Onyeka, Janelt, Ghoddos; Lewis-Potter, Mbeumo, Wissa
ARSENAL
Out: Jurrien Timber (knee), Thomas Partey (groin), Gabriel Martinelli (hamstring), David Raya (ineligible), Declan Rice (back), Leandro Trossard (muscle), Bukayo Saka (fatigue)
Doubtful: None
Sports Mole's predicted XI: Ramsdale; Cedric, Saliba, Kiwior, Tomiyasu; Havertz, Elneny, Jorginho; Nelson, Nketiah, Smith Rowe
For data analysis of the most likely results, scorelines and more for this match please click here.