The Gunners need to beat the Seagulls, who are one point short of their best Premier League finish, and hope that Tottenham Hotspur and Everton drop points on the final day.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
ARSENAL vs. BRIGHTON & HOVE ALBION
ARSENAL
Out: Mathew Ryan (ineligible)
Doubtful: David Luiz (thigh), Hector Bellerin (leg)
Sports Mole's predicted XI: Leno; Chambers, Holding, Gabriel, Tierney; Xhaka, Partey; Pepe, Odegaard, Saka; Aubameyang
BRIGHTON & HOVE ALBION
Out: Neal Maupay (suspended), Danny Welbeck (hamstring), Solly March (knee), Tariq Lamptey (hamstring)
Doubtful: Joel Veltman (calf), Davy Propper (ankle)
Sports Mole's predicted XI: Sanchez; White, Dunk, Webster; Gross, Bissouma, Lallana, Burn; Mac Allister, Trossard; Zeqiri
Video prediction
Watch the Sports Mole Football Shorts prediction for this game below: