This fixture was last played in front of an empty stadium and now fans can bring the noise once again to this clash that is bound to be lively.
Swansea are level on points with their rivals after an inconsistent start with five draws, four losses and only two wins.
Cardiff have suddenly found themselves losing five in a row in the league and have plummeted to 20th in the table.
McCarthy will be hoping that with the international break the Bluebirds can turn things around as pressure mounts on his job safety.
This tie could prove pivotal for both managers in their seasons and it doesn't get much bigger than playing your bitter rivals.
Here's everything you need to know ahead of the derby.
Swansea vs Cardiff: How to listen
This Championship tie will get under way at 12pm on Sunday, October 17.
Commentary will come from Nigel Adderley and former Scotland striker Chris Iwelumo.
To tune in, click HERE for the live stream.
Swansea vs Cardiff: Team news
The Swans have the advantage at home this weekend and could be boosted by Olivier Ntcham and Michael Obafemi returning to the squad.
Ntcham had a hamstring injury which he sustained at Craven Cottage last month but could be available for the weekend fixture.
Obafemi missed the last three games but could also be fit to play after returning to training.
Both Ethan Laird and Ryan Manning are going to be assessed ahead of the game after picking up knocks.
Cardiff have one long-term absentee Joel Bagan remains out of the squad with a shoulder injury.
But McCarthy will still be weighing up his options prior to the match with no other confirmed injuries over the international break so far.