The Lilywhites are six places and three points worse off than their visitors in the early-season standings, and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. ARSENAL
TOTTENHAM HOTSPUR
Out: Richarlison (unspecified)
Doubtful: Dominic Solanke (ankle), Micky van de Ven (knee), Yves Bissouma (knock)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Bentancur; Kulusevski, Maddison, Son; Solanke
ARSENAL
Out: Declan Rice (suspended), Mikel Merino (shoulder), Kieran Tierney (hamstring), Takehiro Tomiyasu (knee)
Doubtful: Gabriel Jesus (groin), Riccardo Calafiori (calf), Martin Odegaard (ankle)
Sports Mole's predicted XI: Raya; White, Saliba, Gabriel, Timber; Havertz, Partey, Jorginho; Saka, Jesus, Martinelli
For data analysis of the most likely results, scorelines and more for this match please click here.