The Dutch will be looking to make up for lost time, having missed out on the 2018 tournament in Russia, while Senegal are bidding to emulate the heroes of 2002, who reached the quarter-finals.
However, the AFCON champions have been robbed of their star man by injury, with Sadio Mane having been ruled out of the entire tournament.
Here, Sports Mole compares both squads to see how they stack up ahead of Monday's meeting.
SENEGAL
Most valuable player:
Kalidou Koulibaly (£30.4m)
Overall squad value:
£199.3m
Most capped player:
Idrissa Gueye (96)
Leading goalscorer:
Ismaila Sarr & Famara Diedhiou (10)
Total caps:
543
Total goals:
39
Oldest player:
Idrissa Gueye (33)
Youngest player:
Pape Matar Sarr (20)
Average age:
25.9
SQUAD IN FULL
Goalkeepers: Edouard Mendy (Chelsea), Alfred Gomis (Rennes), Seny Dieng (Queens Park Rangers)
Defenders: Kalidou Koulibaly (Chelsea), Fode Ballo-Toure (AC Milan), Pape Abou Cisse (Olympiacos), Youssouf Sabaly (Real Betis), Ismail Jakobs (Monaco), Formose Mendy (Amiens), Abdou Diallo (RB Leipzig), Moussa N'Diaye (Anderlecht)
Midfielders: Idrissa Gueye (Everton), Nampalys Mendy (Leicester City), Cheikhou Kouyate (Nottingham Forest), Pathe Ciss (Rayo Vallecano), Krepin Diatta (Monaco), Pape Matar Sarr (Tottenham Hotspur), Moustapha Name (Pafos), Mamadou Loum (Reading), Pape Gueye (Marseille)
Forwards: Nicolas Jackson (Villarreal), Boulaye Dia (Salernitana), Ismaila Sarr (Watford), Famara Diedhiou (Alanyaspor), Bamba Dieng (Marseille), Iliman Ndiaye (Sheffield United)
NETHERLANDS
Most valuable player:
Matthijs de Ligt (£60.8m)
Overall squad value:
£510.1m
Most capped player:
Daley Blind (94)
Leading goalscorer:
Memphis Depay (42)
Total caps:
683
Total goals:
105
Oldest player:
Remko Pasveer (39)
Youngest player:
Xavi Simons (19)
Average age:
26.6
SQUAD IN FULL
Goalkeepers: Justin Bijlow (Feyenoord), Andries Noppert (Heerenveen), Remko Pasveer (Ajax)
Defenders: Virgil van Dijk (Liverpool), Nathan Ake (Manchester City), Daley Blind (Ajax), Jurrien Timber (Ajax), Denzel Dumfries (Inter Milan), Stefan de Vrij (Inter Milan), Matthijs de Ligt (Bayern Munich), Tyrell Malacia (Manchester United), Jeremie Frimpong (Bayer Leverkusen)
Midfielders: Frenkie de Jong (Barcelona), Steven Berghuis (Ajax), Davy Klaassen (Ajax), Teun Koopmeiners (Atalanta BC), Marten de Roon (Atalanta BC), Kenneth Taylor (Ajax), Xavi Simons (PSV Eindhoven)
Forwards: Cody Gakpo (PSV Eindhoven), Memphis Depay (Barcelona), Steven Bergwijn (Ajax), Vincent Janssen (Antwerp), Luuk de Jong (PSV Eindhoven), Noa Lang (Club Brugge), Wout Weghorst (Besiktas)