Steve Clarke's side have endured a difficult few weeks after the Tartan Army missed out on a place at the 2022 World Cup in Qatar.
Scotland bounced back in their opening Nations League game with a routine victory in the reverse fixture with Armenia.
But they were then trounced 3-0 by Ireland on Saturday and Clarke will need to galvanise his squad to close the three-point gap on leaders Ukraine.
Armenia v Scotland: talkSPORT commentary
This Nations League clash will take place on Tuesday, June 14.
talkSPORT 2 will have live coverage of the showdown at the Vazgen Sargsyan Republican Stadium which will kick-off at 5pm.
Commentary will come from Alex Crook and former Scotland defender Steven Pressley.
talkSPORT 2 will then broadcast Wales' away fixture against the Netherlands immediately following this one.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Armenia v Scotland: Team news
The hosts may be without Artak Dashyan after he was forced off with an injury during the latter stages of the 3-0 defeat against Ukraine.
As for Scotland, captain Andy Robertson may finally be given a rest following an exhausting season with Liverpool.
Aaron Hicky could be drafted in as his replacement, with Kieran Tierney still out injured.
Armenia v Scotland: What has been said?
Scotland boss Steve Clarke: "We have to win there.
"It's that simple now and it might be an ugly one or might be a pretty one - but we need to win. 'Must wins' are not really in my vocabulary. But we have to bounce back from what's been another disappointment.
"For me, the biggest thing is that we had disappointment against Ukraine, and then did OK, and then it's disappointment again.
"I have to analyse that and find out why that happened.
"I felt the game last Wednesday was a good game for the players because they were able to dominate possession.
"But Ireland got about us and we couldn't handle it for some reason.
"So that's what I need to go away and look at.
"The result and the performance, nobody could see it coming."