Venezia vs. Genoa (Saturday, 2.00pm)
Still in search of their first win since returning to Serie A, Venezia welcome Genoa to Stadio Pier Luigi Penzo on Saturday.
The Lagunari sit rock-bottom of the early standings, while their visitors scored a late equaliser last time out and have five points on the board so far.
We say: Venezia 1-2 Genoa
Venezia are trying to follow in the footsteps of Genoa, who stayed up with room to spare following promotion, but they have looked a little out of their depth so far.
A leaky back line could leave the hosts vulnerable to conceding multiple goals again, so their wait for a win will go on.
Juventus vs. Napoli (Saturday, 5.00pm)
Two Serie A giants will go toe to toe in Turin, as Juventus host Antonio Conte's Napoli on Saturday evening.
While Juve are still unbeaten and made an impressive Champions League return in midweek, the visitors have bounced back from a first-day defeat to collect maximum points from their next three matches.
We say: Juventus 1-1 Napoli
It promises to be a tight tactical battle between two intense coaches, as a couple of Calcio heavyweights scrap it out on Saturday evening.
Napoli have attempted the most shots so far in Serie A (72), but well-drilled Juventus have faced the fewest (25) and could grind out another draw.
Lecce vs. Parma (Saturday, 7.45pm)
Both with four points from as many Serie A matches so far, Lecce and Parma will lock horns at Stadio Via del Mare on Saturday evening.
While the hosts have recently recovered from starting with back-to-back defeats, their Emilian counterparts have twice let leads slip to end up empty-handed.
We say: Lecce 1-2 Parma
Parma have conceded goals in each of their last 27 Serie A away games - the longest ongoing streak without a clean sheet on the road - and Lecce may take advantage of their naivety to extend that run.
However, the Crociati have been pretty impressive since returning to Italy's top tier, and this time they can retain a lead and take three points back to Emilia-Romagna.