Los Blancos' title hopes were dealt a blow on Sunday after they played out a goalless stalemate on home soil with Real Sociedad.
Carlo Ancelotti's men can ill-afford to drop any more points if they wish to retain their top-flight title, and they could head into Thursday's contest eight points behind current La Liga leaders Barcelona if they beat Real Betis on Wednesday.
Here, Sports Mole rounds up Real Madrid's latest injury and suspension news ahead of the contest with Gennaro Gattuso's side.
Ferland Mendy
Status: Major doubt
Type of injury: Thigh
Possible return date: February 2 vs. Valencia
Ferland Mendy sustained a thigh injury in the first half of Real Madrid's Copa del Rey win over rivals Atletico Madrid last week, and he now faces a race against time to be fit for Thursday's contest.
Lucas Vazquez
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Lucas Vazquez sprained his ankle in the Spanish Super Cup semi-final win against Valencia earlier this month and the Spaniard will not recover in time to feature on Thursday.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no suspended players for this match.
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