Ange Postecoglou's Celtic beat AZ Alkmaar in the play-off round to book their place in the tournament proper.
Now, the Hoops will kick off their tricky Group G campaign in Spain this evening.
The Scottish giants will face Real Betis, Bayer Leverkusen and Ferencvaros over the coming weeks and will have to work hard to make it through.
Real Betis v Celtic: Date and time
The Europa League Group G tie will take place on Thursday, September 16.
It will kick off at 5:45pm and is being held at the Benito Villamarin Stadium.
Celtic's second group game will be at home to Leverkusen on Thursday, September 30.
Real Betis v Celtic: TV channel and live stream
The game will be shown live on BT Sport 3, with coverage starting at 5:15pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
talkSPORT Drive with Andy Goldstein & Darren Bent will have goal updates from the match.
To tune in, click the radio player below or HERE for the live stream.
talkSPORT will also have a live blog of all Thursday night's action as it happens.
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Real Betis v Celtic: Team news
Celtic will be without captain Callum McGregor through injury.
Greg Taylor, Kyogo Furuhashi and James Forrest are also out.
Liel Abada will not feature as he is observing the Jewish holiday Yom Kippur.
Right-back Anthony Ralston is available after missing last weekend's win over Ross County.
Real Betis v Celtic: What's been said?
Ange Postecoglou has dismissed any notion that depleted Celtic will head to Real Betis with the aim of playing for a point.
He said: "My philosophy is if you win games, you've got a good chance of progressing. That's irrespective of whether you're home or away, and it's even more so in group stages.
"If you start thinking about scratching around for a point here and there or trying to accumulate a certain amount of points to get through, that's not the kind of football team we want to be.
"We'll go there and try and win a game of football. That doesn't change. Our approach doesn't change.
"It's not that we don't recognise the difficulty of the opposition or playing away from home - I understand all that - but I think playing for those kind of outcomes is inviting danger.
"You're kind of starting off by conceding something and I'm not prepared to concede anything to anyone in any way, shape or form with a team I'm involved in. It's about trying to impose the way we want to play on a very good opponent."