Donny van de Beek and Dean Henderson will both start in Manchester United's final Champions League group game against Young Boys, while Jesse Lingard and Luke Shaw are also in contention after injury.
And in further good news, both Raphael Varane and Edinson Cavani have returned to light training, and are expected to be back working in full from Monday.
Having kicked off the Ralf Rangnick era with Sunday's 1-0 win against Crystal Palace, United return to Old Trafford on Wednesday already assured of finishing top of Group F.
The new boss is ready to rotate his squad ahead of the busy Christmas period, and those plans will be bolstered by United's alleviating injury issues.
Summer signing Varane has been sidelined for the last five weeks with a hamstring injury he suffered in the 2-2 draw at Atalanta, which was also the last time Cavani featured.
Shaw, has missed the last four matches following recent blows to the head while Lingard missed Sunday's game with an ankle complaint.
Rangnick reiterated that he will rotate his side for the visit of Young Boys, with United having already won the group - but that the game has come too early for Varane and Cavani.
"They both cannot play tomorrow but they were part of the traning today," revealed Rangnick. "Edi even yesterday, Rapha the first time. Expect them both in full training next week.
"Both are top players. It is also about sustainability. It would be great to have them as soon as possible, but obviously for more important for the rest of the season."
The United boss did confirm that both Henderson and Van de Beek would be in his starting XI.
"Well to start with they will both play tomorrow, in the first XI," he added. "Donny came on as a sub last Sunday. Dean is a very ambitious 'keeper, we need two."
And he hinted that Lingard too will be involved, stating: "Everybody has the chance to perform and present themselves. I am happy to give game time to quite a few of them tomorrow."
Indeed, Nemanja Matic insists United's star names are currently all vying to impress new boss Rangnick.
"We have to try to impress the manager, that we deserve to play," he said. "We are through, top of the group, but we want the three points at Old Trafford and to show the manager we have quality to play."
The Serbian also spoke glowingly on midfield pair Scott McTominay and Fred, both of whom were vital in the weekend win over Palace.
"I think they are great people, great people for the changing room. They prove a lot game by game.
"They don't get enough praise, always those who score goals do. They will get what they deserve. They are getting better and better.
"They give us stability and will have a bright future."