Man United took a two-goal lead in the first leg at Old Trafford courtesy of a double from Marcel Sabitzer, but late own goals from Tyrell Malacia and Harry Maguire have left the teams level heading into this match.
Match preview
Sevilla were second-best by a considerable distance in the opening 45 minutes against Man United at Old Trafford last week, with Sabitzer's brace handing the Red Devils a 2-0 lead inside the first 21 minutes, and at that stage, it appeared that the English giants would be securing a strong first-leg advantage.
Jose Luis Mendilibar's side had other ideas, though, and they were rewarded for a much-improved second-half performance with two late goals, leaving the tie delicately poised heading into the second leg of the last-eight affair in Andalusia.
There is just something about Los Nervionenses and this competition, lifting the trophy on six occasions, which is a record, and it would certainly not be a shock to see them go all the way once again this season despite their struggles domestically in 2022-23.
Sevilla will have to win the Europa League if they are to be present in next season's Champions League, as a disappointing La Liga campaign has left them down in 13th in the table, 16 points off fourth-placed Real Sociedad.
Mendilibar's team have now picked up seven points from their last three league games, though, including a 2-0 success over Valencia at the weekend, and they will now be looking to reach the semi-finals of the Europa League at Man United's expense, which would be a huge scalp in this season's competition.
Man United really should have been out of sight against Sevilla before the late own goals from Malacia and Maguire, and it proved to be a damaging night in more ways than one, with Lisandro Martinez and Raphael Varane both picking up injuries, and the former's has ruled him out for the rest of the season.
The Red Devils will still be confident of beating Sevilla on Thursday to progress to the final four, but Erik ten Hag's side are picking up injuries at the worst possible stage of the season.
Man United have had a habit of bouncing back quickly from disappointing results, though, and they were excellent in the Premier League on Sunday, recording a 2-0 victory over Nottingham Forest courtesy of goals from Antony and Diogo Dalot, with the result strengthening their grip on a top-four spot in the table.
The 20-time English champions are now third in the division, six points ahead of fourth-placed Tottenham Hotspur with a game in hand, while they will face Brighton & Hove Albion in the semi-finals of the FA Cup on Sunday during a defining period of the campaign.
Man United will not want to make a habit of competing in the Europa League, but they won the competition in 2017, and they are still the favourites to lift the trophy this term despite last week's result at Old Trafford.
The Red Devils are still waiting for their first victory over Sevilla, losing two and drawing two of their previous four meetings, including a defeat in the semi-finals of the Europa League in August 2020.
Sevilla Europa League form:
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L
W
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D
Sevilla form (all competitions):
L
L
W
D
D
W
Manchester United Europa League form:
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D
W
W
W
D
Manchester United form (all competitions):
W
L
W
W
D
W
Team News
Sevilla will be without the services of Gonzalo Montiel, who is suspended due to the yellow card that he picked up in the first leg at Old Trafford last week.
Pape Gueye is also ineligible for the Spanish side in the Europa League, but the home side have no injury concerns, with the players coming through the win over Valencia unscathed.
The bulk of the XI that took to the field for the first leg last week should again start here, with Ivan Rakitic, Oliver Torres, Tanguy Nianzou and Yassine Bounou set to return to the side after being rested from the first whistle against Valencia last time out.
However, there is expected to be a spot at centre-forward for Youssef En-Nesyri, who was surprisingly only a substitute against Man United at Old Trafford, with Erik Lamela picked to lead the line.
As for Man United, Bruno Fernandes is suspended following his yellow card in the first leg last week.
Donny van de Beek, Alejandro Garnacho, Tom Heaton, Martinez and Varane are all definitely out through injuries, while Ten Hag's side have a number of other fitness concerns.
Marcus Rashford, Luke Shaw, Malacia, Scott McTominay and Sabitzer are all doubts, but the situation will become clearer when the team's squad is named on Wednesday.
Maguire and Victor Lindelof should continue in the middle of the defence, while Fred is expected to be brought into the midfield alongside Casemiro and Christian Eriksen.
Rashford is being tipped to return to the squad but might only be a substitute, with Jadon Sancho and Antony set to operate alongside Anthony Martial in the final third of the field.
Sevilla possible starting lineup:
Bounou; Navas, Nianzou, Marcao, Acuna; Fernando, Gudelj; Ocampos, Rakitic, O Torres; En-Nesyri
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Maguire, Lindelof, Shaw; Casemiro, Fred, Eriksen; Antony, Martial, Sancho
We say: Sevilla 1-2 Manchester United
Man United will feel that they should have been out of sight in the first leg, but the Red Devils now face a tough examination in Spain. Sevilla's recent form has been impressive, but we are expecting the Premier League giants to navigate their way into the final four of the competition with a second-leg success.