On the other hand, the away side make the trip to Foxborough in search of a pick-me-up having lost each of their last three matches.
Match preview
New England Revolution fell to a narrow 2-1 defeat at the hands of Los Angeles Galaxy when the sides squared up against each other on Monday.
Bruce Arena's men made a poor start to the game and found themselves two down inside the opening 10 minutes thanks to strikes from Daniel Aguirre and Chicharito before pulling one back through Carles Gil.
The Revs currently sit ninth in the Eastern Conference, two points adrift of Columbus Crew in the race for the last playoff spot albeit having played a game more.
Awaiting them next is the challenge of an opposing outfit who have recorded only one victory in the last meetings between the teams since 2018.
Off the back of a first home defeat since April last time out, Thursday's hosts will be seeking to get back to winning ways on their own patch as soon as possible.
Chicago Fire fell to a second straight home loss in as many games as they were defeated 2-0 by CF Montreal at the Soldier Field on Sunday.
Ezra Hendrickson's men conceded first-half strikes to Ismael Kone and Romell Quioto and failed to muster any significant threat in front of goal.
The Men in red remain bottom but one in the Eastern Conference and their hopes of clinching a place in the postseason continue to diminish as the weeks go by.
New England Revolution Major League Soccer form:
Chicago Fire Major League Soccer form:
Team News
Jacob Jackson and Dyland Borrero are set to be absent for New England Revolution as they continue to battle with muscle and thigh injuries respectively.
Having both made their return to action last time out, Gustavo Bou and Henry Kessler are both expected to feature right from the off here.
Gaston Gimenez has missed each of Chicago Fire's most recent two outings with a knee problem and the 31-year-old is set to sit out Thursday's clash as well.
The away side are also set to be without Wyatt Omsberg through injury, while Stanislav Ivanov also continues his spell on the treatment table.
New England Revolution possible starting lineup:
Petrovic; Bye, Farrell, Kessler, Jones; Makoun, Polster, McNamara; Gil, Boateng, Bou
Chicago Fire possible starting lineup:
Slonina; Sekulic, Teran, Czichos, Bornstein; Torres, Navarro; Gutierrez, Shaqiri, Mueller; Duran