Despite indifferent campaigns for both, the two clubs are still in European contention as we approach the final third of the season.
Match preview
Lille enter the fixture in a strong position to attack the Champions League places in Ligue 1.
Les Dogues are sat in sixth, six points behind Monaco in third, but with all the sides below the top two of Paris Saint-Germain and Marseille showing great inconsistency, the door is open for anybody to take the final place.
Paulo Fonseca's side have won three of their last five matches in the league, and even in the two games where they failed to find three points, they performed well.
Despite falling to defeat against PSG at the Parc des Princes, they scored three times and led with three minutes to go, but were undone by a piece of late magic by Lionel Messi.
The other of those games saw them draw at high-flying Lens last weekend, a result which is wholly respectably given Lens' stubbornness against the best sides in the division this season.
Lille's home form will be key if they are to make a late charge for the top three and it has been excellent up to this point - averaging over two points per game at the Stade Pierre-Mauroy.
They have not lost here since August against Nice, a run which now stretches back 12 games, but they will be tested by a Lyon side capable of so much more than they have shown this season.
Jonathan David could play a pivotal role for the hosts, and it was his equaliser that earned them a point at Lens last time out.
Only Kylian Mbappe has more goals in Ligue 1 this season than the Canadian, and David is on course for his best scoring season in Europe, as he needs three more to beat his 18-goal tally from the 2019-20 season with Gent in Belgium.
The reverse fixture between the sides was Laurent Blanc's home debut in charge, and even though Lyon won, they would go on to pick up just two points from their following four home games.
A notable improvement on their home form of late has helped keep alive very faint hopes of Europe for OL this season though, via the league route.
Blanc's men sit 10th currently, but are just six points off sixth, which, depending on who wins the domestic cup, could be enough for a European place.
Lyon themselves could be one of the sides to win it, as they are now the favourites to win the Coupe de France, having beat their upcoming opponents in the last 16 before seeing off Grenoble to set up a tie with Nantes in the semi-finals.
Toulouse and second-tier Annecy are the other two sides remaining in the competition, so Lyon will hope to keep the winning feeling going in preparation for that crucial semi-final.
Seven wins from their last 10 matches suggests Lyon are headed in the right direction at the moment.
Lille Ligue 1 form:
D
W
W
L
W
D
Lille form (all competitions):
W
L
W
L
W
D
Lyon Ligue 1 form:
D
W
W
L
W
D
Lyon form (all competitions):
W
W
L
W
W
D
Team News
Bafode Diakite missed Lille's draw with Lens at the weekend with a thigh injury, and the right-back is expected to miss out again.
After scoring in back-to-back games, Diakite will evidently be a big miss at both ends, as Gabriel Gudmundsson could deputise for him again.
There is a problem on the opposite flank too, as left-back Ismaily is still out, also with a thigh injury, but credit is due to Timothy Weah, who has filled in excellently in defence despite naturally being an attacking winger.
Adam Ounas, who has not featured since early January, is Lille's other absentee, as the Algerian has a leg injury.
Lyon's injury list is much more daunting for manager Blanc, with absentees all over the pitch.
Goalkeeper Anthony Lopes is out after breaking his finger last week, and after allowing Julian Pollersbeck to go on loan to Lorient in January, 35-year-old Remy Riou has been drafted in to deputise.
In defence, Jerome Boateng remains a long-term absentee, but more worryingly, Malo Gusto is still out with a hamstring injury.
Further forward, Thiago Mendes is still nursing a groin injury, and Jeffinho remains out, but top scorer Alexandre Lacazette is back in training and could feature in some capacity.
Lille possible starting lineup:
Chevalier; Gudmundsson, Jose Fonte, Tiago Djalo, Weah; Andre, Andre Gomes, Ang. Gomes; Cabella, David, Bamba
Lyon possible starting lineup:
Riou; Diomande, Lovren, Lukeba, Tagliafico; Lepenant, Caqueret, Tolisso; Barcola, A Sarr, Cherki
We say: Lille 2-1 Lyon
Both clubs are among the sides in form in Ligue 1 at the moment so it is tough to separate them.