The Argentine is no stranger to being involved in the biggest domestic fixtures having featured in a joint-record 45 El Clasico's at Barcelona.
The Parisians usurped Bordeaux as Marseille's chief domestic rivals in the late 1980s and early '90s and the game has since become France's fiercest derby.
Only last season, Neymar was one of FIVE players sent-off during a post-match brawl in which he punched rival player Alvaro Gonzalez.
Marseille v Paris Saint Germain: Date and time
Jorge Sampaoli's side will host PSG at the Stade Velodrome on Sunday, October 24.
The Ligue 1 clash will kick off at 7:45pm.
PSG fans have been banned from attending Sunday's derby over fears of crowd trouble.
Marseille v Paris Saint Germain: TV channel and live stream
The top of the table battle will be broadcast live on BT Sport 2 with live coverage starting from 7:15pm.
BT Sport customers can live stream this via the app using their mobile, tablet or computer devices.
Marseille v Paris Saint Germain: Team news
The hosts have a clean bill of health to choose from with Amine Harit fit enough to make the bench against Lazio on Thursday.
As for PSG, Neymar remains a doubt for Sunday's clash after he missed the 3-2 Champions League win over RB Leipzig on Tuesday.
The Brazilian was absent with a groin injury but the issue is not feared to be serious and he will be given every chance to face Marseille.
The away side also continue to be without Leandro Paredes until after the next international break while Sergio Ramos is still waiting on his PSG debut.
Mauro Icardi's off-the-field issues - which also ruled him out in midweek - appear to have settled meaning the forward should return to the squad.
Marseille v Paris Saint Germain: What has been said?
Mauricio Pochettino on how Messi has adapted to life in France.
He said: "Leo shines with his own light. He is a player who shone in Barcelona, who shines in Argentina and at Paris Saint-Germain by himself.
"He's completely integrated; he's a player with the highest level of intelligence and adaptability.
"He is much quieter with the time and the experience accumulated over the past few months than he has been in this club and in this city.
"We are satisfied, happy. And he is very happy to be here in Paris.
"We hope that everything will go as naturally as possible, that he will perform as he hopes and as we hope. I have no doubt that it will turn out that way."