The long-range effort, which came after a rather comical miss, saw Man United beat their Spanish opponents 5-1 on aggregate in the last-16 tie.
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It's now 26 goals in all competitions for Rashford this season, meaning he's now moved above Barcelona hotshot Robert Lewandowski for strikes this season.
In fact, Erling Haaland (39) and Kylian Mbappe (31) are the only players from Europe's top five leagues to have scored more times than Rashford this term.
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Rashford beat Betis goalkeeper Rui Silva as his strike from 25 yards out nestled into the bottom right-hand corner.
It happened moments after Rashford missed a sitter as he uncharacteristically ballooned the ball over the bar despite being through on goal from approximately ten yards out.
Man United could be joined by Arsenal in the last eight, although the Gunners have to get past Sporting Lisbon, who they played out a 2-2 draw with in Portugal last week.
Catch all the latest updates from Arsenal vs Sporting on our live blog.
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