The Red Devils missed out on any silverware this calendar year and sacked Ole Gunnar Solskjaer but did manage to re-sign Cristiano Ronaldo.
Interim boss Ralf Rangnick is yet to suffer defeat in charge of United, but his side laboured to a 1-1 draw with struggling Newcastle on Monday.
Burnley, meanwhile, have not been in action since a 0-0 stalemate with West Ham back on December 12 and remain in the relegation zone.
Both sides will be desperate to secure a victory and that could make this a hugely competitive encounter.
Premier League clash to kick-off at Old Trafford at 8.15pm
United will be hoping to bounce back from a 1-1 draw with Newcastle earlier this week
Man United: De Gea, Wan-Bissaka, Shaw, Maguire, Bailly, McTominay, Matic, Greenwood, Sancho, Cavani, Ronaldo.
Subs: Henderson, Alex Telles, Dalot, Varane, Fred, Lingard, Van De Beek, Elanga, Rashford
Burnley: Hennessey, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Cork, Westwood, McNeil, Lennon, Wood
Subs: Norris, Collins, Bardsley, Pieters, Stephens, Thomas, Vydra
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