Despite securing a last-gasp victory over Atalanta in the Champions League midweek, Ole Gunnar Solskjaer finds himself under pressure after going three Premier League matches without a win.
If he's to pick up three points this weekend then the Norwegian knows that his team will need to be on song.
Jurgen Klopp's side have been in wonderful form this term and find themselves in second place in the top flight and just one point from top spot.
A thrilling victory over Atletico Madrid midweek has seen their confidence grow even further ahead of what will no doubt be a fiercely-contested encounter.
Manchester United team news
Bruno Fernandes, Fred and Marcus Rashford all start for Ole Gunnar Solskjaer's side against Liverpool.
The biggest call is that Paul Pogba is named on the bench.
Here's the United team in full.
Man United XI | De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Bruno Fernandes, Rashford, Greenwood, Cristiano Ronaldo
Subs | Henderson, Bailly, Pogba, Lingard, Dalot, Cavani, Sancho, Matic, Van de Beek
Liverpool team news
Sadio Mane has been named on the bench for the clash with Man United.
Diogo Jota and Roberto Firmino join Mo Salah in attack, while Curtis Jones returns to the bench.
Here's the Liverpool team in full.
Liverpool XI | Alisson, Alexander-Arnold, Van Dijk, Konate, Robertson, Keita, Milner, Henderson, Jota, Firmino, Salah
Subs | Adrian, Mane, Gomez, Oxlade-Chamberlain, Jones, Minamino, Tsimikas, Origi, Matip
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