Both managers going into the match under a bit of pressure with Brendan Rodgers' side amassing just eight points from their opening seven league matches.
Man United are only two points off the top of the Premier League, however, a draw and a defeat in their last two outings as well as struggles in the Carabao Cup and Champions League has led to speculation surrounding Ole Gunnar Solskjaer's future.
Nevertheless the Red Devils will be considered favourites to win at the King Power Stadium, with Solskjaer able to call on a star-studded attack containing the likes of Mason Greenwood, Jadon Sancho and of course Cristiano Ronaldo.
But the Foxes can take heart from Man United being not so secure in defence with Raphael Varane and Harry Maguire set to miss the King Power Stadium clash.
Leicester proved they could get past a fearsome Man United attack and penetrate their shaky defence, which had Rafael, Jonny Evans, Tyler Blackett and Marcos Rojo when they came back from 3-1 down to claim a memorable 5-3 victory in September 2014.
Leicester, who had just come up from the Championship, made a slow start with four points from as many matches, while Louis van Gaal's Man United were only a point better off.
The visitors were heavy favourites going into it though with Man United boasting the likes of Wayne Rooney, Robin van Persie and summer signings Radamel Falcao and Angel Di Maria going forward.
The absentees of Phil Jones and Ashley Young as well as the decision to bench Chris Smalling, Luke Shaw and Antonio Valencia seemed irrelevant.
And Leicester fans will have been fearing the worst when their team went 2-0 down after 16 minutes - the first seeing Van Persie nodding in a pinpoint cross by Falcao on the left, while the second, scored by Di Maria, was a delightful chip which left Kasper Schmeichel and the Leicester defenders in awe.
Leonardo Ulloa hit back straight away with a fine header from a Jamie Vardy cross but the contest looked all over on 57 minutes when Ander Herrera diverted Di Maria's effort past Schmeichel.
It turned out the action was only just about to begin.
The final half an hour was all Leicester and proved to be the making of Vardy, who was playing non-league football just three years earlier, in the top flight.
He didn't score the second goal but the build-up to it was vintage Vardy - the striker chased a long ball down the channel and won it back off Rafael with a cheeky shoulder barge, which on another day could have been judged as a push in the back.
Rafael, fiery in nature, was hell-bent on getting the ball back and leaving a bit on his opponent too. The Brazilian went about it all the wrong way as he sent Vardy tumbling inside the box and referee Mark Clattenburg gave Leicester a penalty which David Nugent slotted down the middle.
Vardy turned provider once again for Leicester's equaliser, albeit in fortunate circumstances. The ball went loose after Vardy accidentally blocked a weak shot but quick as a flash Esteban Cambiasso was onto it to drill home.
The goal saw Man United captain for the day Rooney go into a state of apoplexy but things were about to get so much worse them.
The turnaround was complete on 79 minutes as Vardy showed great composure to net his first Premier League goal after former United man Richie De Laet set him away moments after dispossessing Juan Mata.
Vardy continued to be Man United's tormentor-in-chief as he won another penalty after being tripped over by Blackett, the challenge earning the young centre-back a red card. Ulloa's calm penalty sealed a remarkable win for Leicester.
There were plenty of more difficult days for Leicester that season but this match helped them in their development hugely and was arguably a key moment in helping them avoid relegation and setting them on the path to Premier League glory the following season.
The lack of Varane and Maguire for the clash this weekend will have Vardy, who's made a pretty quiet start to the season, licking his lips once again.