Pep Guardiola's side needed a second-half penalty to scrape past ten-man Wolves on Saturday to continue to remain above rivals Liverpool and Chelsea.
The latter relied on two spot-kicks of their own in their 3-2 win over Leeds, who will now be out to replicate their famous victory at the Etihad last term.
Marcelo Bielsa's team have managed just one win during their eight away games this season and are just five points above the relegation zone.
Manchester City v Leeds: Date and kick-off time
This Premier League clash will take place on Tuesday, December 14.
It will be held at the Etihad in Manchester, with a UK kick-off time of 8pm.
City are winless in four Premier League games against Leeds, who won 2-1 in this fixture last season by scoring with both shots they had in the match.
Manchester City v Leeds: talkSPORT commentary
This game will be broadcast live and exclusive on talkSPORT 2 with coverage starting at 7:45pm.
Commentary will come from Ian Danter and former Manchester City and Leeds defender Danny Mills.
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Manchester City v Leeds: Team news
The hosts have an almost clean bill of health for this fixture with Ferran Torres remaining the only long-term absentee for City.
Speaking in his pre-match press conference, Guardiola said: "Everyone is fit except Ferran."
City will be missing Joao Cancelo as well, however, as the full-back is suspended for an accumulation of yellow cards.
Leeds meanwhile have been plagued with injuries in recent weeks, with Patrick Bamford, Kalvin Phillips and Liam Cooper all out with hamstring issues.
Rodrigo is still struggling with heel pain and Robin Koch remains a doubt following a recent bout of illness.
Pascal Struijk has also added to Leeds' recent injury woes with an inflamed knee.
Manchester City v Leeds: Match facts
Manchester City are winless in four Premier League games against Leeds (D2 L2) since a 2-1 win at Maine Road under Kevin Keegan in January 2003.
Leeds won this exact fixture 2-1 last season, scoring with both shots they had across the whole match. They've not won consecutive away league games against Man City since 1987, while they haven't done so in the top-flight since a run of three between 1969 and 1971.
Leeds have won just one of their last 14 away games against reigning top-flight champions (D5 L8), beating Arsenal 3-2 at Highbury in May 2003.
Leeds have won just two of their 20 Premier League games against sides starting the day top of the table (D9 L9). However, both of these wins have come away from home, including a 2-1 victory over Manchester City in their most recent such encounter.
Manchester City are unbeaten in their last 14 Premier League home games played on Tuesday (W10 D4), with their last such defeat coming at Maine Road in August 1993 against Blackburn Rovers.
Since their return to the division last season, Leeds have won six of their seven midweek (Tuesday, Wednesday, Thursday) Premier League games (L1), including winning all five on Tuesdays.
Manchester City have scored 499 goals in 206 Premier League games under Pep Guardiola - a goal here would see the Spaniard become the manager to see his sides score 500 in the competition in the fewest games from the start of his tenure (currently Jürgen Klopp, 234 games).
Leeds have scored twice in each of their last two Premier League games, having scored more than once in just two of their first 14 this season. However, they've drawn with Brentford (2-2) and lost to Chelsea (2-3) in these games, with West Ham the last side to score at least twice but fail to win 3+ consecutive Premier League matches (4 in a row in March/April 2016).
Raphinha has scored in four of his five league appearances (80%) on Tuesdays for Leeds United, netting four goals. In the club's history, the only player to score in as many as 80% of their league appearances on a day of the week (min. 5 games) is Rod Belfitt, who scored in four of his five league games on Wednesdays between 1964 and 1971.
Joe Gelhardt scored with his first touch in Leeds' defeat against Chelsea last time out; the last teenager to score in back-to-back Premier League appearances for the Whites was James Milner in December 2002, who did so after coming on as a substitute in both matches versus Sunderland and then Chelsea.