The manager has refused to put an official timeframe on their return, although said both strikers are 'feeling positive'.
Reports earlier this week claimed Lukaku could be facing up to a month on the sidelines, after he limped off in the first-half of Chelsea's 4-0 win over Malmo on Wednesday.
The striker, who was re-signed for £97.5million from Inter Milan this summer, twisted his ankle during the Champions League victory.
Werner was also injured in that match, with the German forward hobbling off just before half-time.
A month out would see the striker miss Premier League games against Norwich, Newcastle, Burnley and Leicester, Southampton in the Carabao Cup and a return to Malmo in the Champions League.
Speaking in his press conference ahead of Saturday's clash with bottom side Norwich, the Blues boss said: "Romelu, Timo and Christian are all out for tomorrow.
"There's no big news for Romelu and Timo; I can say they are out for tomorrow and they will be out for the Southampton game and from there we see what's next.
"I don't think it makes any sense that we go into speculation about how long it's going to be.
"If we'd done this with Christian Pulisic you'd think maybe I'm a liar, constantly lying and hiding something.
"But the fact is you never know, things can be shorter than expected or they can be longer than expected.
"The one thing I can tell you for sure is that they are both in treatment, they are both feeling positive, they are not too worried and are out for the next two games for sure, and then we'll see."
Both strikers unavailable could be a huge blow to the Blues' title hopes
Tuchel will now have to turn to Kai Havertz - who scored the winning goal in the Champions League final earlier this year - to lead the line.
The German attacker has scored just twice in all competitions so far this season, but he will need to step up now his strike partners are unavailable.
Tuchel had admitted Lukaku had been 'overplayed', leaving him mentally tired due to a hectic schedule for club and country ahead of his injury against Malmo.
Asked if even an unwanted rest could benefit Lukaku now, Tuchel replied: "No, it's never a good thing, honestly, never a good thing.
"I cannot see a positive thing from this injury.
"This role as favourites that we have now for some matches, it was a perfect role for Romelu to take pressure off others people's shoulders, to take the responsibility.
"He was and is mentally a bit overplayed, like others in our squad, but that doesn't mean that we constantly have to rest them.
"Jorginho and Mason Mount are in exactly the same spot, but they played a fantastic match.
"So it is like this, they played a lot of competitions, they played a lot of competitions with a lot of enthusiasm and personal targets.
"And this is what we felt with Romelu.
"So we encouraged him to trust his instincts and let us do the thinking and the organising of the structure that he will be able to have the last contact.
"This is what we did for the Malmo game, and in a role as a favourite he would be absolutely crucial for us.
"But honestly we cannot now constantly talk about who is injured, we have to find solutions and we will find solutions because we trust our squad.
"And the guys who stepped in played a good match and it's up to them to keep on going tomorrow."
Christian Pulisic will also miss the Norwich clash due to his nagging ankle issue, leavin Havertz and Callum Hudson-Odoi likely to partner Mount in a three-man forward line.
USA forward Pulisic has not featured since the Premier League's opening day, and his frustrating elongated recovery has left boss Tuchel reluctant to make snap judgements on the Blues' new injury concerns.