Arne Slot's men are the only team in the competition with 12 points under their belt from their opening four games, most recently demolishing Xabi Alonso's Bayer Leverkusen 4-0 to move two points clear at the top of the UCL table.
While Liverpool's lead in Europe is not insurmountable, their Premier League advantage is, as they opened up an eight-point gap over Manchester City with a thrilling 3-2 victory over Southampton on Sunday.
Here, Sports Mole rounds up all of Liverpool's latest injury and suspension news ahead of their clash with the holders, who have won just two of their opening four battles to languish in 18th spot.
Trent Alexander-Arnold
Status: Major doubt
Type of injury: Hamstring
Possible return date: November 27 (vs. Real Madrid)
Trent Alexander-Arnold sat out the victory over Southampton with the hamstring issue he sustained in the win over Aston Villa before the international break, and Reds fans are waiting with bated breath to learn whether he will be fit for the midweek encounter.
Diogo Jota
Status: Out
Type of injury: Abdominal
Possible return date: December 7 (vs. Everton)
Diogo Jota's abdominal concern is proving more difficult to overcome than initially anticipated, and Slot does not expect him to return for the meeting with Real Madrid or Manchester City at the weekend.
Alisson Becker
Status: Out
Type of injury: Hamstring
Possible return date: December 4 (vs. Newcastle United)
Similarly, Alisson Becker's hamstring problem is set to rule him out of Liverpool's two crunch matches in the coming week, although a comeback in early December should still materialise.
Federico Chiesa
Status: Major doubt
Type of injury: Fitness
Possible return date: November 27 (vs. Real Madrid)
Federico Chiesa has finally been seen on the training pitches again as he bids to overcome a troublesome period of niggles, but even if he is considered for selection here, he will only make the bench at best.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for this match, but Alexis Mac Allister and Ibrahima Konate will miss the Reds' next Champions League game if they are booked on Wednesday.