Jurgen Klopp's side kept their hopes of securing the top spot in Group A of the Champions League alive on Wednesday when they steamrolled Rangers 7-1 at the Ibrox Stadium, with Mohamed Salah coming off the bench to net a sensational six-minute hat-trick.
The Reds, who are unbeaten in four consecutive games against Pep Guardiola's side, will set out to breathe life into the Premier League campaign as they have picked up just 10 points from their opening eight games to sit 10th in the league standings, 14 points adrift of first-placed Arsenal.
Here, Sports Mole rounds up Liverpool's latest injury and suspension news ahead of their clash with Manchester City, who were denied a seventh consecutive victory on Tuesday courtesy of a goalless draw with Copenhagen in the Champions League.
Trent Alexander-Arnold
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Trent Alexander-Arnold missed the trip to Rangers on Tuesday after sustaining an ankle injury against Arsenal last weekend and the England international is out of contention for the clash against Manchester City.
Luis Diaz
Status: Out
Type of injury: Knee
Possible return date: December 26 (vs. Aston Villa)
Luis Diaz was forced off injured three minutes before half time against Arsenal last Sunday and while the Colombian forward will require no surgery, he is expected to be sidelined until after the World Cup.
Joel Matip
Status: Out
Type of injury: Calf
Possible return date: Unknown
Joel Matip was another injury casualty from the 3-2 defeat against the Gunners last weekend as the experienced defender suffered a calf strain that saw him sit out the game against Rangers. The 31-year-old, who has four league appearances under his belt this season, is out of contention for the Reds.
Arthur Melo
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Arthur Melo, who has played just 13 minutes for Liverpool since his deadline-day loan move from Juventus, is set to be sidelined until the new year after suffering an injury in training last week which required surgery.
Alex Oxlade-Chamberlain
Status: Out
Type of injury: Thigh
Possible return date: October 29 (vs. Leeds United)
Alex Oxlade-Chamberlain, whose last appearance for Liverpool in July's 2-0 win over Crystal Palace, is currently recuperating from a thigh injury and the 29-year-old will also play no part in Sunday's game.
Curtis Jones
Status: Calf
Type of injury: Major doubt
Possible return date: October 16 (vs. Manchester City)
Curtis Jones has made positive progress on his return from a calf injury he sustained in July's Community Shield victory against Manchester City and the Englishman could make his return from the sidelines this weekend.
Naby Keita
Status: Out
Type of injury: Knee
Possible return date: October 29 (vs. Leeds United)
Naby Keita is yet to feature for Liverpool in the league this season — with his last appearance coming in the Community Shield — but while the midfielder is nearing a return to full fitness, he is out of contention for Sunday's game.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for the match against Manchester City.