Spurs are looking to do their first league double over the Red Devils since the 1989/90 season following their 2-0 win in August.
Despite skipper Son Heung-min, Yves Bissouma and Pape Matar Sarr away on international duty, as well as James Maddison sidelined through injury, Ange Postecoglou still looks set to name a strong side.
In what has been a brilliant week for the north Londoners, they have managed to secure the loan transfer of ex-Chelsea forward Timo Werner from RB Leipzig.
And talkSPORT understands they are poised to announced the arrival of Romanian defender Radu Dragusin having fended off interest from Bayern Munich.
Tottenham are also set to be boosted by the return of World Cup-winning centre-back Cristian Romero.
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According to The Athletic, the 25-year-old, who has been out with a hamstring knock, is pushing to feature at Old Trafford.
Postecoglou now has all his first-choice defenders at his disposal, and could have Dragusin to count on if he is registered in time.
Here talkSPORT predicts how Spurs, who would move back inside the top four with a win at United, could start in Sunday's 4:30pm clash.
Guglielmo Vicario will keep his place between the sticks, with the Italian undoubtedly one of the signings of the summer transfer window.
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Pedro Porro, whose stunning strike against Burnley earned Spurs a place in the FA Cup fourth round, will likely keep his place at right-back.
Destiny Udogie would then feature on the opposite side, with Romero to return to the heart of defence.
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Postecoglou may decide against throwing Dragusin immediately into the deep end, and instead start Micky Van de Ven, who like Romero, has been battling a hamstring knock.
Despite not featuring since the 4-1 defeat against Chelsea in October, the Dutchman was on the bench for the 1-0 win over the Clarets in a sign he is ready to be called upon.
Uruguay international Rodrigo Bentancur could then start as a lone defensive midfielder, with Oliver Skipp and Dejan Kulusevski deployed in the free-roaming No.8 roles.
Werner may then start on the left wing as he had done for Chelsea often during his two-year spell between 2020-2022.
Brennan Johnson would then feature on the opposite flank, with Richarlison leading the line.