The Lilywhites returned to winning ways with a 4-1 battering of Newcastle United at the weekend, and victory this week would see them temporarily go level on points with Manchester City in the table.
All of Alfie Whiteman (ankle), Manor Solomon (knee), Ivan Perisic (knee), Ryan Sessegnon (thigh), James Maddison (ankle), Rodrigo Bentancur (ankle), Ashley Phillips (ankle) and Micky van de Ven (hamstring) remain unavailable for Tottenham, who are also expected to make do without Eric Dier (groin) for at least another week or two.
As a result, Ben Davies should continue in a central role alongside Cristian Romero and Guglielmo Vicario, both of whom were involved in unsavoury incidents with Callum Wilson on Sunday evening.
Romero was only given a yellow card for a late challenge on Wilson, who then accused Vicario of a "lack of respect" after the Spurs number one pulled a face at him towards the end of the game.
Out wide, Destiny Udogie will bomb down the left after celebrating his first Tottenham goal with a contract extension until 2030, while Pedro Porro continues to provide a creative flair on the right.
Yves Bissouma and Pape Sarr's unbreakable partnership is now going strong again, and amid interest from Barcelona over a January loan move, Giovani Lo Celso could be overlooked for a starting role again.
Indeed, Dejan Kulusevski is primed to feature in the number 10 role, as Brennan Johnson and Son Heung-min also provide support to Richarlison, who scored his first two Spurs goals with his feet against the Magpies.
Tottenham Hotspur possible starting lineup: Vicario; Porro, Romero, Davies, Udogie; Sarr, Bissouma; Johnson, Kulusevski, Son; Richarlison