The Blades are again without the services of Billy Sharp, Jack O'Connell and Oli McBurnie, while Ethan Ampadu has been ruled out for the remainder of the 2020-21 campaign due to pelvic problems.
Head coach Paul Heckingbottom also revealed during Friday's pre-match press conference that Oliver Burke has suffered a fractured foot and will miss the remainder of the season.
Sander Berge was involved against Crystal Palace last time out, but there will be no risks taken with the midfielder following a long spell on the sidelines, and he is therefore unlikely to start here.
Berge's spot in the middle of the park could be taken by Ben Osborn, while Rhian Brewster is in contention to replace Burke in the final third of the field.
David McGoldrick is a certain starter in attack, while John Fleck, Oliver Norwood, George Baldock and Enda Stevens should retain their spots for the Blades, who are heading back to the Championship for the 2021-22 campaign.
Heckingbottom, though, suggested on Friday that some of the club's Under-23s could be involved in this match.
Sheffield United possible starting lineup: Ramsdale; Basham, Egan, Bryan; Baldock, Fleck, Norwood, Osborn, Stevens; McGoldrick, Brewster
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