Meanwhile, their attacking line has taken a major hit with Billy Sharp, Oli McBurnie and Oliver Burke all ruled out of action.
Those absentees, coupled with Rhian Brewster's failure to hit the ground running in Sheffield, paved the way for 17-year-old Daniel Jebbison to start his first Premier League match in their trip to Everton last week, and he had the perfect full debut, netting the only goal of the game in the seventh minute to fire his side to an impressive win.
The Canadian-born forward again started in the midweek trip to Newcastle United, and he should be handed a third straight start on Sunday.
He will be joined by David McGoldrick, who has scored seven and assisted one of the Blades' 19 Premier League goals this campaign.
The injury concerns do not stop there for interim manager Paul Heckingbottom either, as right-back George Baldock and midfielder Sander Berge remain doubts, with Jayden Bogle expected to continue on the right-hand side in Baldock's absence.
Without the Norweigan midfielder, Heckingbottom should again line up with a midfield three of Ben Osborn, Oliver Norwood and John Fleck, given John Lundstram's failed contract renewal negotiations.
After a tough first half of the season upon his return to Sheffield United from AFC Bournemouth, goalkeeper Aaron Ramsdale has been a shining light in a poor Blades campaign, keeping them in plenty of games in the back end of the season thanks to an abundance of eye-catching saves.
Sheffield United possible starting XI: Ramsdale; Basham, Egan, Robinson; Bogle, Osborn, Norwood, Fleck, Stevens; Jebbison, McGoldrick