The French champions were without the services of six first-team players for their 3-1 win over Lens last time out and that will again be the case for this match.
Indeed, Timothee Pembele, Renato Sanches, Marco Verratti, Nordi Mukiele, Presnel Kimpembe and Neymar remain on the sidelines for the title hopefuls.
Kylian Mbappe and Lionel Messi were both on the scoresheet in the victory over Lens, and the pair should again feature as the front two in a 3-5-2 formation in this match.
Marquinhos was withdrawn late on in the team's last game but is fit to start here, while Nuno Mendes and Achraf Hakimi should again operate as the wing-backs.
Fabian Ruiz, Vitinha and Carlos Soler should play as the midfield three, while Sergio Ramos and Danilo are expected to retain their spots in the starting XI.
Juan Bernat and Warren Zaire-Emery are both options to come into the side on Friday, but the pair are again expected to be among the substitutes for the first whistle.
Paris Saint-Germain possible starting lineup: Donnarumma; Marquinhos, Ramos, Danilo; Hakimi, Soler, Ruiz, Vitinha, Mendes; Messi, Mbappe