The Argentina World Cup winner returned to training to a guard of honour from his teammates last week, and Christophe Galtier can also count on Neymar again following his suspension.
As a result, Messi, Kylian Mbappe and Neymar are ready to reunite in the final third of the field, as Galtier reverts to his strongest XI after beating Chateauroux in the Coupe de France.
The injury-plagued Renato Sanches will hope to recover from a bruise in time to make the squad, but he seemingly has little chance of a midfield start over Vitinha, Marco Verratti or Fabian Ruiz.
Further back, Achraf Hakimi will serve his own suspension for an accumulation of yellow cards, allowing Nordi Mukiele the opportunity to bomb down the right after seemingly shaking off an injury scare from the win over Chateauroux.
Presnel Kimpembe and Nuno Mendes also remain sidelined for PSG, whose backline ought to comprise Mukiele, Marquinhos, Sergio Ramos and Juan Bernat in front of Gianluigi Donnarumma - back in for Keylor Navas after a rare start for the Costa Rican in the Coupe de France.
PSG possible starting lineup: Donnarumma; Mukiele, Marquinhos, Ramos, Bernat; Vitinha, Verratti, Ruiz; Messi; Mbappe, Neymar