Scott McTominay was missing during a training session on Wednesday, with the Scotland international instead doing a recovery gym session, and there have been claims that he could miss out on a spot in the side.
As a result, Van de Beek, who is battling to prove himself this summer, could feature in midfield alongside Fred and Bruno Fernandes, with this fixture marking the team's final match of their Thailand and Australia tour.
Raphael Varane and James Garner were both on the sidelines for the clash with Palace last time out, and it is unclear whether they will be involved on Saturday due to their fitness problems.
Victor Lindelof could again feature alongside Harry Maguire if Varane is not risked, with Luke Shaw potentially returning at left-back at the expense of Tyrell Malacia.
Jadon Sancho and Marcus Rashford have both scored twice this summer and should keep their spots in the side, with the pair enjoying themselves under Ten Hag, while Anthony Martial is set to lead the attack once again.
Martial - back at the club following an unsuccessful loan spell at Sevilla - has scored three times in three friendly fixtures this summer, with the Frenchman thriving in the absence of Cristiano Ronaldo.
Alejandro Garnacho is yet to play a minute this summer and will hope to feature on Saturday, while the likes of Hannibal Mejbri, Charlie Savage, Zidane Iqbal and Facundo Pellistri will also be battling for more minutes.
Manchester United possible starting lineup: De Gea; Dalot, Maguire, Lindelof, Shaw; Fred, Van de Beek, Fernandes; Rashford, Martial, Sancho