Foden remains on the sidelines with a foot injury, while De Bruyne is not yet in full training with his Man City teammates due to an ankle problem, so the duo will miss out at the Tottenham Hotspur Stadium.
Man City boss Pep Guardiola, though, revealed during Friday's press conference that Raheem Sterling, John Stones, Kyle Walker, Ederson and Gabriel Jesus were all available for selection after international commitments.
Stones, Walker and Ederson could come straight into the first XI this weekend, although Nathan Ake, Zack Steffen and Benjamin Mendy are on standby if required.
Fernandinho could potentially join Rodri and Ilkay Gundogan in the middle of the park, while Ferran Torres might be given the chance to operate as the false nine for the English champions.
Riyad Mahrez seems certain to feature on the right for the visitors, while Jack Grealish is in line to make his Premier League debut, having arrived in a £100m deal from Aston Villa.
Grealish was used off the bench in last weekend's 1-0 defeat to Leicester City in the Community Shield but is now expected to be pressed into action from the start.
Man City possible starting lineup: Ederson; Walker, Stones, Dias, Cancelo; Gundogan, Rodri, Fernandinho; Mahrez, Torres, Grealish
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