Zack Steffen is also out following a positive coronavirus test, meaning that there could be a rare start between the sticks for Scott Carson, who has only ever made one appearance for the Citizens.
Aymeric Laporte is available despite suffering an injury scare on international duty, while Man City are hopeful that both Phil Foden and Kevin De Bruyne will be able to play a part at the King Power Stadium.
It seems unlikely that either Foden or De Bruyne will start, though, meaning that Raheem Sterling, Jack Grealish and Ferran Torres could feature as the front three on Saturday afternoon.
Bernardo Silva wanted to leave the Etihad Stadium over the summer but has remained at the club, and the Portugal international is in line to start if De Bruyne is not deemed fit enough to make the first XI.
Kyle Walker and John Stones both represented England over the international break and are likely to start despite the latter seemingly picking up a small muscular problem during his nation's clash with Poland.
Elsewhere, Ruben Dias and Joao Cancelo should feature, while Rodri and Ilkay Gundogan are likely to be handed midfield positions for the reigning English champions.
Manchester City possible starting lineup: Carson; Walker, Stones, Dias, Cancelo; Bernardo, Rodri, Gundogan; Grealish, F Torres, Sterling