The Reds lost Ryan Gravenberch to a hamstring injury in their 0-0 draw with Manchester United at the weekend, although Klopp is still none the wiser about how serious the Dutchman's issue is.
Either way, it would be a shock to see Gravenberch involved in midweek, where Alexis Mac Allister is also classed as a major doubt due to the knee injury he suffered against Sheffield United earlier this month.
Thiago Alcantara (hip), Stefan Bajcetic (calf), Andrew Robertson (shoulder), Joel Matip (ACL) and Diogo Jota (muscle) make up a quintet of definite absentees for Liverpool, who will no doubt offer opportunities to a few second-string performers.
The first alteration should occur in goal, where Caoimhin Kelleher will expect to get the nod over Alisson Becker, while Jarell Quansah and Joe Gomez could form a new-look central pairing.
Gomez being deployed in front of Alisson would allow Trent Alexander-Arnold and Kostas Tsimikas to reprise their roles out wide, unless Klopp springs a surprise by starting Conor Bradley or Luke Chambers.
Wataru Endo is seemingly safe as Liverpool's number six given a lack of alternative options, but Gravenberch and Dominik Szoboszlai - who did not enjoy his finest display for Liverpool on Sunday - could make way for Curtis Jones and Harvey Elliott.
Mohamed Salah failed to score or assist at Anfield for the first time this season against Man United, but the Egyptian should hold off the threat of Ben Doak to start in attack, most likely with Luis Diaz and Cody Gakpo accompanying him.
Liverpool possible starting lineup: Kelleher; Alexander-Arnold, Gomez, Quansah, Tsimikas; Elliott, Endo, Jones; Salah, Gakpo, Diaz