The Reds will confirm a top-two finish in the group if they avoid defeat against the Austrian side, while a victory would also send them through to the last 16 as group winners if Toulouse cannot beat Union SG.
Thiago Alcantara (hip), Stefan Bajcetic (calf) and Andrew Robertson (shoulder) are known absentees for Liverpool, but the Reds also saw Alisson Becker and Diogo Jota sustain injuries in Saturday's Premier League draw with Manchester City.
Jota had to be forced off early in the second half, while Alisson picked up his problem just before City's final corner of the match and had to play through the pain, as Klopp had already made his five allocated substitutions.
It is unclear how severe either man's issue is at present, but Alisson was always expected to make way for Caoimhin Kelleher, who could be protected by a new-look pairing of Jarell Quansah and Ibrahima Konate.
Allegedly risking punishment by celebrating in front of the Man City fans at the weekend, Trent Alexander-Arnold may retain his place at right-back - with the captain's armband in tow - but Joe Gomez is a contender to replace Kostas Tsimikas on the left.
After battling back from a knee injury, Ryan Gravenberch could also be reintroduced into the engine room, as should be the case for Wataru Endo and Harvey Elliott as well.
In the final third, Luis Diaz will surely be a straight swap for the stricken Jota, while Cody Gakpo and Ben Doak are also in line to replace Darwin Nunez and Mohamed Salah respectively.
Liverpool possible starting lineup: Kelleher; Alexander-Arnold, Konate, Quansah, Gomez; Elliott, Endo, Gravenberch; Doak, Gakpo, Diaz