The Argentina international was rested for Inter's Good Friday draw at Salernitana, with Romelu Lukaku and Angel Correa starting in tandem up top.
Hakan Calhanoglu is doubtful for the encounter, having sustained a muscle injury playing for Turkey against Croatia during the last international break and has not featured for Inter since club football returned.
Centre-back Milan Skriniar may be on his way out of the club in the summer but it potentially hurts the Nerazzurri that the defender is unlikely to feature in Portugal due to back trouble.
The 28-year-old has not played for Inter since the goalless encounter with Porto in mid-March and is not expected to return in time for Tuesday.
Alessandro Bastoni, Stefan de Vrij and Danilo D'Ambrosio could start in the three-man defence, ahead of Andre Onana, who was left embarrassed by Salernitana's equaliser on Friday.
Apart from Dalbert, who suffered a cruciate ligament injury last July, Simone Inzaghi has no long-term injury worries in his team, and the Nerazzurri boss' team will not be unfamiliar to observers.
Federico Dimarco could come into the lineup for Robin Gosens, despite the former Atalanta wide defender's goal in Salerno, with Inzaghi often leaning on the Italy international for these huge games.
Marcelo Brozovic was a second-half substitute on Friday, and the midfielder should return to the team's midfield, with Nicolo Barella and Henrikh Mkhitaryan flanking the Croatian.
Inter possible starting lineup: Onana; D'Ambrosio, De Vrij, Bastoni; Darmian, Barella, Brozovic, Mkhitaryan, Dimarco; Martinez, Dzeko