Primarily up front in his favoured 3-5-2 formation, coach Simone Inzaghi has shuffled his resources more than usual, but having left both Lautaro Martinez and Edin Dzeko on the bench against Roma at the weekend, the pair could be promoted in tandem.
The recent revival of Romelu Lukaku, though, may cause Inzaghi to alter his plans in that regard, as while Joquin Correa is almost certain to make way, the Belgian striker could beat Dzeko to selection and reprise his 'Lu-La' partnership with Martinez.
A confirmed Inzaghi favourite, Henrikh Mkhitaryan was also among the substitutes for Saturday's game at Stadio Olimpico, but he is expected to beat Hakan Calhanoglu - who scored a stunning against Hellas Verona last week - to a start in central midfield.
Nicolo Barella and Marcelo Brozovic will join him, while Denzel Dumfries features on the right flank and Federico Dimarco on the left.
Alternatives to the latter pair are thin on the ground for the Nerazzurri, as Matteo Darmian is likely to be part of the back three in Milan Skriniar's continued absence and Dimarco's main competition Robin Gosens is still sidelined by a dislocated shoulder.
In better news for Inzaghi, Danilo D'Ambrosio should return to the Inter squad after overcoming a muscular problem; providing an experienced back-up for several defensive positions.
Inter Milan possible starting lineup: Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Dimarco; Martinez, Lukaku